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Tocris Bioscience™ TM2 TEAD inhibitor
Potent and reversible inhibitor of TEAD mediated Hippo/Yap signalling
Marke: Tocris Bioscience™ 7917/50
470.83 EUR gültig bis 2024-12-16
Benutzen Sie den Promotions-Code "21630" um Ihren Promotions-Preis zu erhalten.
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Beschreibung
TM2 TEAD inhibitor is a potent and reversible TEA domain transcription factor inhibitor (IC50 = 38 nM and 156 nM for TEAD4 auto-palmitoylation and TEAD2 palmitoylation, respectively). It inhibits TEAD-YAP association and transcriptional activity. TM2 TEAD inhibitor exhibits strong antiproliferation effects as a single agent or in combination with a MEK inhibitor in YAP-dependent cancer cells. Also inhibits YAP-dependent liver organoid growth ex vivo.Spezifikation
| 4-[3-(2-Cyclohexylethoxy)benzoyl]-N-phenyl-1-piperazinecarboxamide | |
| 50 mg | |
| C26H33N3O3 |
| 1008768-41-9 | |
| YAP1 | |
| 0.98 |