STEMCELL Technologies Phorbol 12-myristate 13-acetate

PKC pathway activator; Activates protein kinase C

Marke: STEMCELL Technologies 74042

Artikelnummer. 17160312

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Beschreibung

Phorbol 12-myristate 13-acetate (PMA), a phorbol ester, is a reversible, highly potent activator of protein kinase C (PKC), including Group A and Group B isoforms (Blumberg)
PMA activates PKC isoforms through the binding of the C1 domain (Hurley et al.) PMA can also activate certain mitogen-activated protein (MAP) kinase pathways through PKC (Adams & Parker)
Stimulates cardiac differentiation of mesenchymal stem cells (Seo et al.)
Promotes hematopoietic differentiation (Clemens et al.)
Stimulates differentiation of IL-15-stimulated lamina propria CD4+ T cells into CXCR5+CD4+ cells when used together with ionomicin (Sarra et al.)
In combination with AS101, it shows anti-leukemic activity and stimulates human leukemia cell lines to differentiate into macrophage-like cells (Glesne & Huberman; Hayun et al.)

Spezifikation

Synonym	12-O-Tetradecanoylphorbol-13-acetate; PMA; TPA
Summenformel	C₃₆H₅₆O₈

Produktvorschläge

Beschreibung