Learn More
Tocris Bioscience™ Pexidartinib
Potent CSF-1R inhibitor
Marke: Tocris Bioscience™ 7590/50
Weitere Details : CAS : 1029044-16-3 Netto-Gewicht : 0.00970kg
Beschreibung
Pexidartinib is a potent colony-stimulating factor-1 receptor (CSF-1R) tyrosine kinase inhibitor (IC50 = 20 nM). In the B16F10 mouse melanoma model, Pexidartinib reduces the systemic and local accumulation of macrophages without affecting Gr-1+ myeloid derived suppressor cells. When combined with tumor-specific CD8 T cell immunotherapy, Pexidartinib promotes the control of tumor growth. In the BRAFV600E-driven mouse melanoma model, Pexidartinib improves the efficacy of adoptive cell therapy with reduction of TIMs and an increase in tumor-infiltrating lymphocytes and T cells. Orally bioavailable.Spezifikation
N-[5-[(5-Chloro-1 H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-6-(trifluoromethyl)-3-pyridinemethanamine | |
50 mg | |
C20H15ClF3N5 |
1029044-16-3 | |
Additional RTK Inhibitors | |
98% |