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NeutraKine IL-17A Mouse anti-Human, Unconjugated, Clone: 1F3E3, Proteintech
Mouse Monoclonal Antibody
Marke: Proteintech 69021-1-IG-25UG
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Beschreibung
IL17A, also named as IL-17, is a proinflammatory cytokine. IL-17, synthesized only by memory T cells and natural killer cells, has pleiotropic effects, mainly in the recruitment and activation of neutrophils. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The IL-17 receptor is a type I transmembrane protein, that is widely expressed on epithelial cells, fibroblasts, B and T cells, and monocytic cells. In psoriatic skin lesions, both Th17 cells and their downstream effector molecules, e.g. IL-17 and IL-22, are highly increased. This antibody is used to Block/Neutralize IL-17A protein.
Spezifikation
| NeutraKine IL-17A | |
| Monoclonal | |
| Unconjugated | |
| 25 μg | |
| 3605 | |
| Liquid |
| Neutralization, ELISA | |
| 1F3E3 | |
| Mouse | |
| Primary | |
| Human, Mouse, Rat | |
| IgG1 |