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Tocris Bioscience™ GSK 626616
Potent and selective DYRK inhibitor; orally bioavailable.
Marke: Tocris Bioscience™ 6638/10
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Beschreibung
GSK 626616 is a potent and selective DYRK inhibitor (IC50 = 0.7 nM for DYRK3, similar potency for DYRK1 and 2). Exhibits ∽20-fold selectivity over casein kinase 2 and negligible activity against a panel of 451 kinases screened. Enhances number of CFU-E stimulated by Epo from human marrow. Increases hemoglobin levels in anemic mice. Orally bioavailable.Spezifikation
| (5Z)-2-[(2,6-Dichlorophenyl)amino]-5-(6-quinoxalinylmethylene)-4(5H)-thiazolone | |
| 10 mg | |
| 401.27 |
| 1025821-33-3 | |
| C18H10Cl2N4OS | |
| 98% |