STEMCELL Technologies Valproic Acid (Sodium Salt)

Beschreibung

• VaL^proic Acid (VPA) is a short-chain fatty acid that acts as an epigenetic modifier by inhibiting Histone Deacetylases (HDACs) with IC₅₀ values ranging from 0.4 - 3 mM
• VPA can also increase γ­aminobutyric acid (GABA) levels via inhibition of enzymes involved in GABA metabolism
• Other effects include depletion of cellular inositol by inhibiting myo-inositol-1-phosphate synthase
• (Gottlicher et al.), Khan et al.), Phiel et al.), Rosenberg)
• Enables chemical reprogramming (without genetic factors) of mouse embryonic fibroblasts to induced pluripotent stem (iPS) cells, in combination with CHIR99021, Forskolin, Tranylcypromine, 3-Deazaneplanocin A, and E-616452 (Hou et al.)
• Increases the reprogramming efficiency of mouse embryonic fibroblasts to iPS cells (Huangfu et al. 2008a)
• Promotes reprogramming of human fibroblasts to iPS cells using only 2 factors, OCT4 and SOX2 (Huangfu et al. 2008b)
• Direct lineage reprogramming of fibroblasts to mature neurons, in combination with CHIR99021, RepSox, Forskolin, SP600125, Gö6983 and Y-27632 (Hu et al.)
• Mediates ex vivo expansion of cord blood CD34+ hematopoietic stem and progenitor cells (Chaurasia et al.)
• Promotes the proliferation and self-renewal of human and mouse hematopoietic progenitor cells (Bug et al.), De Felice et al.)
• Promotes differentiation of neurons and suppresses differentiation of astrocytes and oligodendrocytes from rat neural progenitor cells (Hsieh et al.), Jung et al.)
• Promotes osteogenic differentiation of human mesenchymal stem cells (Cho et al.)