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Tocris Bioscience™ TH 9619 disodium salt
MTHFD2 inhibitor
Marke: Tocris Bioscience™ 7719/50
512.61 EUR gültig bis 2024-12-16
Benutzen Sie den Promotions-Code "21630" um Ihren Promotions-Preis zu erhalten.
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Beschreibung
TH 9619 disodium salt is a potent and selective methylenetetrahydrofolate dehydrogenase inhibitor (MTHFD2; IC50 = 47 nM). It shows efficacity on HL-60 cell viability with EC50 of 11nM. In vitro, It shows antiproliferative efficacy in acute myeloid leukemia (AmL) cells and T-ALL Jurkat cells. In vivo, TH9619 disodium salt impairs cancer progression in a mouse disease model of AmL.Spezifikation
| Disodium N-[[5-[[2-(2,4-Diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)acetyl]amino]-3-fluoro-2-pyridinyl]carbonyl]-L-glutamate | |
| Dehydrogenase Inhibitors | |
| 0.98 |
| 50 mg | |
| C17H16FN7Na2O7 |