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TCS ERK 11e, Tocris Bioscience™
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Menge:
10 mg
Beschreibung
Potent and selective extracellular signal-related kinase 2 (ERK2) inhibitor (Ki values are <2, 395, 540 and 852 nM for ERK2, GSK-3, Aurora Kinase A and Cdk2 respectively). Potently blocks proliferation of HT29 cells (IC50 = 48 nM). Orally bioavailable.
Spezifikation
Spezifikation
| Chemischer Name oder Material | TCS ERK 11e |
| CAS | 896720-20-0 |
| Summenformel | C24H20Cl2FN5O2 |
| Menge | 10 mg |
| Synonym | vx-11e, vtx-11e, vx 11e, 4-2-2-chloro-4-fluorophenyl amino-5-methylpyrimidin-4-yl-n-1s-1-3-chlorophenyl-2-hydroxyethyl-1h-pyrrole-2-carboxamide, vertex-11e, pyrimidylpyrrole, 11e, tcs erk 11e, vx-11e tcs erk 11e, 4-2-2-chloro-4-fluoroanilino-5-methylpyrimidin-4-yl-n-1s-1-3-chlorophenyl-2-hydroxyethyl-1h-pyrrole-2-carboxamide, 4-2-2-chloro-4-fluorophenyl amin-o-5-methyl-4-pyrimidinyl-n-1s-1-3-chlorophen-yl-2-hydroxyethyl-1h-pyrrole-2-carboxamide |
| InChI-Schlüssel | WUTVMXLIGHTZJC-OAQYLSRUSA-N |
| SMILES | CC1=CN=C(N=C1C2=CNC(=C2)C(=O)NC(CO)C3=CC(=CC=C3)Cl)NC4=C(C=C(C=C4)F)Cl |
| IUPAC-Name | 4-[2-(2-chloro-4-fluoroanilino)-5-methylpyrimidin-4-yl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide |
| Molekulargewicht (g/mol) | 500.355 |
| PubChem CID | 11634725 |
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