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T-bet Monoclonal Antibody (eBio4B10 (4B10)), eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
Marke: Invitrogen 14-5825-80
106.67 EUR gültig bis 2025-03-21
Benutzen Sie den Promotions-Code "24111" um Ihren Promotions-Preis zu erhalten.
Benachrichtigungen:
Um den Rabatt von 33.33 % zu erhalten, müssen Kunden drei Einheiten desselben Produkts zum Listenpreis in einer einzigen Bestellung kaufen. Es gibt keine Begrenzung für die Anzahl von 3er Sets, die Kunden kaufen können. PCODE: 24111
Beschreibung
Description: The eBio4B10 monoclonal antibody reacts with mouse and human T-bet. T-bet is a Th1-specific T-box transcription factor critical to the development of the Th1 CD4+ T cell lineage. This is known based on the observations that T-Bet deficient mice have impaired Th1 cell development, and that ectopic expression of T-Bet results in development skewed to the Th1 lineage. T-Bet expression is induced by the Th1 cytokine IFN gamma, and T-Bet also regulates the expression of IFN gamma, likely, at least in part, through the modification of DNA accessibility and histone remodeling. In addition to IFN gamma, T-Bet is also known to regulate the expression of IL-12R beta and IL-2. Moreover, T-Bet plays a role in class-switch recombination in B-cells. Applications Reported: This eBio4B10 antibody has been reported for use in immunohistochemical staining of formalin-fixed paraffin embedded tissue sections (with citrate antigen retrieval), immunoprecipitation, and immunoblotting (WB). Applications Tested: This eBio4B10 antibody has been tested by western blot analysis of Th1-polarized mouse CD4+ T cells and can be used at 2 μg/mL as a starting dilution for western blotting. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered.
T-bet, also known as TBX21, is a T-cell specific transcription factor containing a single T-box DNA-binding domain. It controls the expression of the TH1 cytokine, interferon-gamma. Both Th1 and Th17 cells are crucial in immune regulation and autoimmune disease development. T-bet initiates Th1 lineage development from naive Th precursor cells and directs T cell differentiation to Th1 versus Th17. T-bet is cooperating with Stat4 (signal tranducer and activator of transcription 4) in programming chromatin architecture for Th1 gene expression. Genetic variations in T-bet are associated with susceptibility to aspirin-induced asthma and nasal polyps.
Spezifikation
T-bet | |
Monoclonal | |
0.5 mg/mL | |
PBS with 0.09% sodium azide; pH 7.2 | |
Q9JKD8, Q9UL17 | |
Tbx21 | |
Affinity chromatography | |
RUO | |
30009, 57765, 694044 | |
4° C | |
Liquid |
Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot | |
eBio4B10 (4B10) | |
Unconjugated | |
Tbx21 | |
HGNC:11599; LOW QUALITY PROTEIN: T-box transcription factor TBX21; Tbet; T-bet; TBLYM; T-box 21; T-box expressed in T cells; T-box protein 21; T-box transcription factor 21; T-box transcription factor TBX21; TBT1; TBX21; T-cell-specific T-box transcription factor T-bet; T-PET; transcription factor TBLYM; transcription factor T-box 21 | |
Mouse | |
25 μg | |
Primary | |
Human, Mouse, Rhesus Monkey | |
Antibody | |
IgG1 κ |
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For Research Use Only.