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  6. ST 034307, Tocris Bioscience™

ST 034307, Tocris Bioscience™

Artikelnummer. 30000965
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Menge:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Adenylyl cyclase 1 (AC1) inhibitor; analgesic and active in vivo

ST 034307 is an adenylyl cyclase 1 (AC1) inhibitor (IC50 = 2.3 μM). Exhibits some selectivity for AC1 over other AC isoforms, with no significant activity against AC8. Inhibits Ca2+/calmodulin-stimulated cAMP accumulation in hippocampal homogenates. Enhances μ opioid receptor (MOR)-mediated inhibition of AC1 in cellular assays and inhibits development and maintenance of MOR-mediated sensitization of AC1. ST 034307 relieves pain without causing tolerance in mouse models of pain. Active in vivo. Analgesic.

Chemical Identifiers

CAS 133406-29-8
Summenformel C10H4Cl4O2
Molekulargewicht (g/mol) 297.94
InChI-Schlüssel NTDHYMSVCBGQJF-UHFFFAOYSA-N
Synonym ST 034307
PubChem CID 867466
IUPAC-Name 6-chloro-2-(trichloromethyl)chromen-4-one
SMILES C1=CC2=C(C=C1Cl)C(=O)C=C(O2)C(Cl)(Cl)Cl

Specifications

Chemischer Name oder Material 6-Chloro-2-(trichloromethyl)-4H-1-benzopyran-4-one
Strukturformel C10H4Cl4O2
Menge 50 mg
Löslichkeitsinformationen Soluble to 100mM in DMSO and to 20mM in ethanol
Formelmasse 297.95
Reinheit (%) >98%
Physikalische Form Solid
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