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Ribavirin, Tocris Bioscience™
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Menge:
50 mg
Beschreibung
Antiviral guanosine ribonucleoside analog; misincorporated into mRNA by viral-dependent RNA polymerases. Binds to and redistributes mammalian eIF4E from the nucleus to the cytoplasm (Ki ∽ 0.3 μM for the active metabolite, ribavirin triphosphate). Also inosine monophosphate dehydrogenase (IMPDH) inhibitor. Represses colony formation of primary AML-M5 progenitor cells (IC50 ∽ 1 μM); reduces disease severity in acute myeloid leukemia (AML). Inhibits cytopathic effect of SARS-CoV in Vero cells in vitro. Orally available.
Spezifikation
Spezifikation
| Chemischer Name oder Material | Protein-synthesizing GTPase Compounds |
| CAS | 36791-04-5 |
| Summenformel | C8H12N4O5 |
| Menge | 50 mg |
| Synonym | ribavirin, tribavirin, virazole, rebetol, ribavirine, copegus, vilona, ribamide, ribamidil, ribasphere |
| InChI-Schlüssel | IWUCXVSUMQZMFG-AFCXAGJDSA-N |
| SMILES | C1=NC(=NN1C2C(C(C(O2)CO)O)O)C(=O)N |
| IUPAC-Name | 1-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazol-3-carboxamid |
| Molekulargewicht (g/mol) | 244.207 |
| PubChem CID | 37542 |
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