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Invitrogen™ RAP80 Recombinant Rabbit Monoclonal Antibody (24GB4080)
Rabbit Recombinant Monoclonal Antibody
Marke: Invitrogen™ MA557308
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Beschreibung
RAP80 Recombinant Monoclonal Antibody for Western Blot, ICC/IF
RAP80 was initially identified as zinc-finger containing nuclear protein that is highly expressed in testis and interacts with the retinoid-related testis-associated receptor (RTR). Later experiments revealed that RAP80 is recruited by the Coiled-coil domain 98 (CCDC98) protein to the breast cancer-1 protein BRCA1, allowing the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation. Both RAP80 and CCDC98 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair. Cells depleted of either RAP80 or CCDC98 exhibited increased sensitivity to ionizing radiation, although not as much as in BRCA1-depleted cells, suggesting that RAP80 and CCDC98 control only part of the DNA damage response role of BRCA1. At least four isoforms of RAP80 are known to exist.
Spezifikation
| RAP80 | |
| Recombinant Monoclonal | |
| Unconjugated | |
| UIMC1 | |
| 9430016E08Rik; BRCA1-A complex subunit RAP80; D330018D10Rik; D630032M02Rik; RAP80; Receptor-associated protein 80; retinoid X receptor interacting protein 110; retinoid X receptor-interacting protein 110; RGD1307009; RIP110; Rxrip110; ubiquitin interaction motif containing 1; ubiquitin interaction motif-containing protein 1; Uimc1; X2HRIP110 | |
| Rabbit | |
| Affinity chromatography | |
| RUO | |
| 51720 | |
| -20°C | |
| Liquid |
| Western Blot, Immunocytochemistry | |
| 24GB4080 | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
| Q96RL1 | |
| UIMC1 | |
| A synthesized peptide derived from human RAP80 (aa 1-59). | |
| 20 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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