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Tocris Bioscience™ PRT 4165
Inhibitor of Bmi1/Ring1A; blocks histone H2A ubiquitination
Marke: Tocris Bioscience™ 5047/10
101.08 EUR gültig bis 2024-12-16
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Beschreibung
PRT 4165 is an inhibitor of Bmi1/Ring1A, subunits of the polycomb repressive complex 1 (PRC1); inhibits self-ubiquitination (IC50 = 3.9 μM) but does not increase cellular levels of either subunit. Prevents Bmi1/Ring1A-mediated ubiquitination and drug-induced degradation of topoisomerase 2α (Top2α). Also shown to inhibit the in vitro E3 ubiquitin ligase activity of RNF2 and a Bmi1/RNF2 complex, inhibiting H2A/H2AX ubiquitination. Blocks polycomb repressor complex (PRC) 1-mediated histone H2A ubiquitination in vitro.Spezifikation
| >99% | |
| PRT 4165 | |
| PRT 4165 |
| 10 mg | |
| 235.24 |
Nur für Forschungszwecke