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Monastrol, Tocris Bioscience™

Artikelnummer. 30001232
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Menge:
10 mg
50 mg
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Beschreibung

Selective inhibitor of mitotic kinesin Eg5

Potent, cell-permeable, small molecule mitosis inhibitor that does not interact with tubulin. Arrests cells in mitosis and specifically inhibits the motility of the mitotic kinesin Eg5, a motor protein required for mitotic spindle formation and maintenance (IC50 = 14 μM).

Chemische Identifikatoren

CAS 254753-54-3
Summenformel C14H16N2O3S
Molekulargewicht (g/mol) 292.353
InChI-Schlüssel LOBCDGHHHHGHFA-UHFFFAOYSA-N
Synonym monastrol, ethyl 4-3-hydroxyphenyl-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate, 4-3-hydroxyphenyl-6-methyl-2-thioxo-1,2,3,4-tetrahydro-4h-pyrimidin-5-carboxylic acid ethyl ester, d0zk2g, monastrol hplc , solid, inverted exclamation marka-monastrol, 6-methyl-4-3-hydroxyphenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate, ethyl 6-3-hydroxyphenyl-2-mercapto-4-methyl-1,6-dihydropyrimidine-5-carboxylate, ethyl 6-3-hydroxyphenyl-4-methyl-2-sulfanyl-1,6-dihydropyrimidine-5-carboxylate, ethyl 6-3-hydroxyphenyl-4-methyl-2-thioxo-1,3,6-trihydropyrimidine-5-carboxy late
PubChem CID 2987927
ChEBI CHEBI:75382
IUPAC-Name ethyl 4-(3-hydroxyphenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylate
SMILES CCOC(=O)C1=C(NC(=S)NC1C2=CC(=CC=C2)O)C

Spezifikation

Chemischer Name oder Material Monastrol
Menge 10 mg
Formelmasse 292.35
Reinheit (%) >98%
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