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Meclizine dihydrochloride, Tocris Bioscience™

Artikelnummer. 18014432
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Menge:
50 mg
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Human pregnane X receptor agonist; H1 antagonist

Meclizine dihydrochloride is a human pregnane X receptor (hPXR) agonist; it is a more potent activator of hPXR than rat PXR. Meclizine increases hPXR target gene expression in human hepatocyte primary cultures. It also acts as a histamine H1 receptor antagonist. Meclizine attenuates mitochondrial respiration and increases glycolysis. The product inhibits rotenone-induced cell death in stem cell-derived dopaminergic neuronal culture and confers neuroprotection in models of polyglutamine (polyQ) toxicity.

Spezifikation

Chemischer Name oder Material Meclizine dihydrochloride
CAS 1104-22-9
Summenformel C25H29Cl3N2
Menge 50 mg
Synonym meclizine dihydrochloride, meclozine dihydrochloride, bonamine, meclizine hydrochloride, postafen, vertizine, taizer, v-cline, 1-4-chlorophenyl phenyl methyl-4-3-methylbenzyl piperazine dihydrochloride, duremesin
InChI-Schlüssel VCTHNOIYJIXQLV-UHFFFAOYSA-N
SMILES CC1=CC(=CC=C1)CN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=C(C=C4)Cl.Cl.Cl
IUPAC-Name 1-[(4-chlorophenyl)-phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine;dihydrochloride
Molekulargewicht (g/mol) 463.871
PubChem CID 64713
Formelmasse 463.87
Reinheit (%) >99%
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