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Lactacystin, Tocris Bioscience™
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Menge:
200 μg
Beschreibung
A cell-permeable, potent and selective proteasome inhibitor. A Streptomyces metabolite that is thought to bind irreversibly to the active site N-terminal threonine residue of the catalytic β-subunit of the 20S proteasome, thereby inhibiting its chymotrypsin and trypsin-like activities. Induces neurite outgrowth in Neuro 2a neuroblastoma cells and has been reported to induce apoptosis in human monoblast U937 cells. Also inhibits NF-κB activation (IC50 = 10 μM).
Spezifikation
Spezifikation
| Chemischer Name oder Material | Lactacystin |
| CAS | 133343-34-7 |
| Summenformel | C15H24N2O7S |
| Synonym | lactacystin, lactacystin synthetic, n-acetyl-s-2r,3s,4r-3-hydroxy-2-1s-1-hydroxy-2-methylpropyl-4-methyl-5-oxopyrrolidin-2-yl carbonyl-l-cysteine, lactacystin hplc, l-cysteine, n-acetyl-, 2r,3s,4r-3-hydroxy-2-1-hydroxy-2-methylpropyl-4-methyl-5-oxo-2-pyrrolidinecarboxylate ester, l-cysteine, n-acetyl-, 3-hydroxy-2-1-hydroxy-2-methylpropyl-4-methyl-5-oxo-2-pyrrolidinecarboxylate ester , 2r-2alpha,2 s* ,3alpha,4alpha, 2r-2-acetamido-3-2r,3s,4r-3-hydroxy-2-1s-1-hydroxy-2-methylpropyl-4-methyl-5-oxopyrrolidine-2-carbonyl sulfanylpropanoic acid, 3s-hydroxy-2r-1-hydroxy-2-methylpropyl-4r-methyl-5-oxo-2-pyrrolidinecarboxylate-n-acetyl-l-cysteine |
| InChI-Schlüssel | DAQAKHDKYAWHCG-RWTHQLGUSA-N |
| SMILES | CC1C(C(NC1=O)(C(C(C)C)O)C(=O)SCC(C(=O)O)NC(=O)C)O |
| IUPAC-Name | (2R)-2-acetamido-3-[(2R,3S,4R)-3-hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxopyrrolidine-2-carbonyl]sulfanylpropanoic acid |
| Molekulargewicht (g/mol) | 376.424 |
| PubChem CID | 6610292 |
| ChEBI | CHEBI:52722 |
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