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DOG1 Mouse Monoclonal Antibody, Epredia™
Obtain accurate, reproducible results in immunohistochemistry experiments with Epredia™ Dog1, Mouse Monoclonal Antibody.
Marke: Epredia MS-1933-R7
Artikelnummer. 12600497
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363.00 €
339.22 € / 7 Milliliter
Sparen 23.78 €
6% Rabatt
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Beschreibung
DOG1 is a cell surface protein of unknown function selectively expressed in gastrointestinal stromal tumors (GIST). Among GIST cases with KIT mutations the DOG1 antibody identified 11% more cases than c-Kit antibody1. DOG1 identifies vast majority of both c-Kit negative and PDGFRA mutated GIST cases that may still benefit from imatinib mesylate (Gleevac), an inhibitor of the kit tyrosine kinase2. In addition, DOG1 immunoreactivity is seen in fewer cases of mesanchymal, epithelial tumors and melanomas when compared with c-Kit. The use of this highly sensitive and specific novel marker will increase the accuracy of GIST diagnosis.Host Species: Mouse
Clone: 1.1
Isotype: Unknown
Species Reactivity: Human. Others not known.
Immunogen: Synthetic peptide of human DOG1
Molecular Weight: 78 kDa
Positive Control: Gastrointestinal Stromal Tumors
Cellular Localization: Cytoplasmic and Membrane
Recommended for:
- Immunohistochemistry (Formalin/paraffin)
Spezifikation
| Dog1 | |
| 1.1 | |
| Unconjugated | |
| Synthetic peptide of human Dog1 | |
| Primary | |
| Ready-to-Use |
| Immunohistochemistry | |
| 200μg/mL | |
| Mouse | |
| 7 mL | |
| Human |
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