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Gibco™ Human SCF Recombinant Protein, PeproTech®
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Menge:
1 mg
10 μg
100 μg
2 μg
250 μg
50 μg
500 μg
Packungsgröße:
1 Milligramm
10 Mikrogramm
100 Mikrogramm
2 Mikrogramm
250 Mikrogramm
50 Mikrogramm
500 Mikrogramm
Beschreibung
Recombinant Human SCF is an 18.4 kDa polypeptide containing 165 amino acid residues, which corresponds to the sequence of the secreted soluble form of SCF. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to homodimerization of the receptor and the activation of signalling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase pathways. SCF expression leads to the induction of mast cell survival and the expression and release of histamine, pro-inflammatory cytokines and chemokines. The inhibition of the SCF/c-Kit pathway leads to a decrease in histamine levels, mast cell and eosinophil infiltration, IL-4 production and airway hyperresponsiveness, suggesting this pathway may be a useful therapeutic target in inflammatory diseases such as asthma. At least two isoforms of SCF are known to exist.
Spezifikation
Spezifikation
| Zugriffsnummer | P21583 |
| Zur Verwendung mit (Anwendung) | ELISA, Functional Assay, Western Blot |
| Zusammensetzung | protein with no preservative |
| Gen-ID (Entrez) | 4254 |
| Molekulargewicht | 18.4 kDa |
| Name | Human SCF |
| Menge | 50 μg |
| Quelle | E. coli |
| Kennzeichnung | RUO |
| Endotoxin-Konzentration | <1 EU/ μg |
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