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Tocris Bioscience™ Go 6976
Potent protein kinase C inhibitor; selective for α and β isozymes
Marke: Tocris Bioscience™ 2253/500U
207.17 EUR gültig bis 2024-12-16
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Beschreibung
Go 6976 is a potent protein kinase C (PKC) inhibitor (IC50 = 7.9 nM). Discriminates between Ca2+-dependent and -independent isoforms of PKC in vitro; selectively inhibits PKCα and PKCβ1 (IC50 values are 2.3 and 6.2 nM respectively). Does not inhibit the activity of PKCδ, -ε, or -ζ (IC50 > 3μM). Also inhibits TrkA, TrkB, JAK2 and JAK3 tyrosine kinases (IC50 values are 5, 30, 130 and 370 nM respectively), PKCμ (PKD1) and the mitotic spindle checkpoint.Spezifikation
| 5,6,7,13-Tetrahydro-13-methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile | |
| 500 μg | |
| C24H18N4O |
| 136194-77-9 | |
| Protein Kinase C Inhibitors | |
| 95% |