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  7. Fasudil hydrochloride, Tocris Bioscience™

Fasudil hydrochloride, Tocris Bioscience™

Artikelnummer. 18094052
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Menge:
10 mg
50 mg
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Beschreibung

Inhibitor of cyclic nucleotide dependent- and Rho-kinases

Fasudil hydrochloride is a cyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor (IC50 = 10.7 μM). Fasudil suppresses MMP-2 expression and induces apoptosis in glioblastoma cells in vivo. Fasudil is a Ca2+ antagonist, vasodilator and inhibits proliferation of vascular smooth muscle cells. Fasudil binds to α-synuclein to reduce aggregate formation in cellular models of Parkinson's disease, also displays neuroprotective properties and increases survival of dopaminergic neurons in vivo.

Chemische Identifikatoren

CAS 105628-07-7
Summenformel C14H18ClN3O2S
Molekulargewicht (g/mol) 327.827
InChI-Schlüssel LFVPBERIVUNMGV-UHFFFAOYSA-N
Synonym fasudil hydrochloride, fasudil hcl, eril, at 877 hydrochloride, fasudil monohydrochloride, ha 1077 hydrochloride, unii-sq04n8s7br, 5-1,4-diazepan-1-yl sulfonyl isoquinoline hydrochloride, sq04n8s7br
PubChem CID 163751
IUPAC-Name 5-(1,4-diazepan-1-ylsulfonyl)isoquinoline;hydrochloride
SMILES C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3.Cl

Spezifikation

Chemischer Name oder Material Fasudil hydrochloride
Menge 10 mg
Formelmasse 327.83
Reinheit (%) >98%
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