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DAPT, Tocris Bioscience™

Artikelnummer. 18083842
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Menge:
10 mg
50 mg
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Gamma γ-secretase inhibitor; induces neuronal differentiation; blocks Notch signaling

DAPT is a γ-secretase inhibitor. DAPT reduces Aβ40 and Aβ42 levels in human primary neuronal cultures (IC50 values are 115 and 200 nM for total Aβ and Aβ42 respectively) and in brain extract, cerebrospinal fluid and plasma in vivo. DAPT has no effect on APPα and APPβ levels. DAPT blocks Notch signaling in hybrid human-mouse fetal thymus organ culture (FTOC) and causes ESCs to commit to neuronal differentiation. DAPT can be used in a small molecule cocktail to derive cortical neurons from hPSCs and to maintain hepatocytes in culture. DAPT also promotes the formation of cone photoreceptors in retinal organoids.

For more information about how DAPT may be used, see our protocols: Accelerated Induction of Cortical Neurons from hiPSCs, Human iPSC-derived Myoblasts, Generating Midbrain Dopaminergic Neurons from hPSCs .

DAPT synthesized to Ancillary Material Grade also available.

Chemische Identifikatoren

CAS 208255-80-5
Summenformel C23H26F2N2O4
Molekulargewicht (g/mol) 432.468
InChI-Schlüssel DWJXYEABWRJFSP-XOBRGWDASA-N
Synonym dapt, dapt gsi-ix, gamma-secretase inhibitor ix, gsi-ix, insolution gamma-secretase inhibitor ix, s-tert-butyl 2-s-2-2-3,5-difluorophenyl acetamido propanamido-2-phenylacetate, n-n-3,5-difluorophenacetyl-l-alanyl-s-phenylglycine t-butyl ester, tert-butyl 2s-2-2s-2-2-3,5-difluorophenyl acetamido propanamido-2-phenylacetate, tert-butyl 2s-2-2s-2-2-3,5-difluorophenyl acetyl amino propanoyl amino-2-phenylacetate, gsiix
PubChem CID 5311272
ChEBI CHEBI:86193
IUPAC-Name Tert-butyl (2S)-2-[[(2S)-2-[[2-(3,5-difluorphenyl)acetyl]amino]propanoyl]amino]-2-phenylacetat
SMILES CC(C(=O)NC(C1=CC=CC=C1)C(=O)OC(C)(C)C)NC(=O)CC2=CC(=CC(=C2)F)F

Spezifikation

Chemischer Name oder Material DAPT
Menge 10 mg
Formelmasse 432.46
Reinheit (%) >99%
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